C9873
Sigma
CPTH2 
≥98% (HPLC), powder
| Synonym: | Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone |
| CAS Number: | 357649-93-5 |
| Linear Formula: | C14H14ClN3S |
| Molecular Weight: | 291.80 |
Description
| Biochem/physiol Actions | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents. |
Properties
| assay | ≥98% (HPLC) |
| form | powder |
| color | light yellow |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
Safety
| WGK Germany | NWG |
References
| reference | Chimenti, F., et al., A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl]hydrazone. J. Med. Chem. 52, 530-536, (2009) |
